Infectivity and reactogenicity of reassortant cold-adapted influenza A/Korea/1/82 vaccines obtained from the USA and USSR.
Identifieur interne : 002282 ( Main/Exploration ); précédent : 002281; suivant : 002283Infectivity and reactogenicity of reassortant cold-adapted influenza A/Korea/1/82 vaccines obtained from the USA and USSR.
Auteurs : K G Nicholson ; D A Tyrrell ; J S Oxford ; J. Wood ; G C Schild ; C W Potter ; R. Jennings ; R H Michaels ; G. AppleyardSource :
- Bulletin of the World Health Organization [ 0042-9686 ] ; 1987.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Vaccins antigrippaux.
- immunologie : Vaccins antigrippaux.
- Adolescent, Adulte, Humains, Virus de la grippe A.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- Adolescent, Adult, Humans, Influenza A virus.
Abstract
The safety and immunogenicity of two live influenza A virus vaccine strains, the CR 59 and 17/25/1 cold-adapted (ca) reassortants, were evaluated in 170 healthy young adult volunteers. The vaccines were produced by recombining A/Korea/1/82 (H3N2) wild-type virus with either A/Ann Arbor/6/60 (H2N2) or A/Leningrad/134/17/57 (H2N2) ca donors of attenuation. Both vaccines were well tolerated in volunteers. The 17/25/1 strain, prepared from A/Leningrad, infected at least 70% of seronegative volunteers after the first dose and 84% after the second; the CR 59 strain infected 62% and 72% of volunteers after first and second doses, respectively. Among the vaccinees who were initially seropositive, 17/25/1 infected 66% after one dose and 85% after two, while CR 59 infected 62% and 71%, respectively. Despite differences in temperature sensitivity, genetic composition, and serological reactivity to monoclonal antibodies, both vaccines behaved almost identically in animal models and man. We conclude that both donors of attenuation may be of great potential value.
PubMed: 3499246
Affiliations:
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Wood</name></author><author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G C" last="Schild">G C Schild</name></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C W" last="Potter">C W Potter</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R" last="Jennings">R. Jennings</name></author><author><name sortKey="Michaels, R H" sort="Michaels, R H" uniqKey="Michaels R" first="R H" last="Michaels">R H Michaels</name></author><author><name sortKey="Appleyard, G" sort="Appleyard, G" uniqKey="Appleyard G" first="G" last="Appleyard">G. 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Wood</name></author><author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G C" last="Schild">G C Schild</name></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C W" last="Potter">C W Potter</name></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R" last="Jennings">R. Jennings</name></author><author><name sortKey="Michaels, R H" sort="Michaels, R H" uniqKey="Michaels R" first="R H" last="Michaels">R H Michaels</name></author><author><name sortKey="Appleyard, G" sort="Appleyard, G" uniqKey="Appleyard G" first="G" last="Appleyard">G. Appleyard</name></author></analytic><series><title level="j">Bulletin of the World Health Organization</title><idno type="ISSN">0042-9686</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Humans</term><term>Influenza A virus</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Humains</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Humans</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Humains</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The safety and immunogenicity of two live influenza A virus vaccine strains, the CR 59 and 17/25/1 cold-adapted (ca) reassortants, were evaluated in 170 healthy young adult volunteers. The vaccines were produced by recombining A/Korea/1/82 (H3N2) wild-type virus with either A/Ann Arbor/6/60 (H2N2) or A/Leningrad/134/17/57 (H2N2) ca donors of attenuation. Both vaccines were well tolerated in volunteers. The 17/25/1 strain, prepared from A/Leningrad, infected at least 70% of seronegative volunteers after the first dose and 84% after the second; the CR 59 strain infected 62% and 72% of volunteers after first and second doses, respectively. Among the vaccinees who were initially seropositive, 17/25/1 infected 66% after one dose and 85% after two, while CR 59 infected 62% and 71%, respectively. Despite differences in temperature sensitivity, genetic composition, and serological reactivity to monoclonal antibodies, both vaccines behaved almost identically in animal models and man. We conclude that both donors of attenuation may be of great potential value.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Appleyard, G" sort="Appleyard, G" uniqKey="Appleyard G" first="G" last="Appleyard">G. Appleyard</name><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R" last="Jennings">R. Jennings</name><name sortKey="Michaels, R H" sort="Michaels, R H" uniqKey="Michaels R" first="R H" last="Michaels">R H Michaels</name><name sortKey="Nicholson, K G" sort="Nicholson, K G" uniqKey="Nicholson K" first="K G" last="Nicholson">K G Nicholson</name><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J S" last="Oxford">J S Oxford</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C W" last="Potter">C W Potter</name><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G C" last="Schild">G C Schild</name><name sortKey="Tyrrell, D A" sort="Tyrrell, D A" uniqKey="Tyrrell D" first="D A" last="Tyrrell">D A Tyrrell</name><name sortKey="Wood, J" sort="Wood, J" uniqKey="Wood J" first="J" last="Wood">J. Wood</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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